ER-phagy at a glance
نویسندگان
چکیده
منابع مشابه
A Role for Macro-ER-Phagy in ER Quality Control
The endoplasmic-reticulum quality-control (ERQC) system shuttles misfolded proteins for degradation by the proteasome through the well-defined ER-associated degradation (ERAD) pathway. In contrast, very little is known about the role of autophagy in ERQC. Macro-autophagy, a collection of pathways that deliver proteins through autophagosomes (APs) for degradation in the lysosome (vacuole in yeas...
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Accumulation of misfolded proteins on intracellular membranes has been implicated in neurodegenerative diseases. One cellular pathway that clears such aggregates is endoplasmic reticulum autophagy (ER-phagy), a selective autophagy pathway that delivers excess ER to the lysosome for degradation. Not much is known about the regulation of ER-phagy. The conserved Ypt/Rab GTPases regulate all membra...
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Peptide and protein drugs have found an important position in therapeutics. Recent advances in pharmaceutical biotechnology have led to an increase in the number of protein products in the market. As these therapeutic proteins and peptides are made available, it will be essential to formulate these drugs into safe and effective delivery systems. The twenty different naturally occurring amin...
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Visual stimulation with precise control of stimulus has transformed the field of psychophysics since the introduction of personal computers. Luminance and chromatic features of stimulus, timing, and position of the stimulus are the main features that could be defined using programs written specifically for psychophysical experiments. In this manuscript, software used for the psychophysical expe...
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Mechanisms of selective autophagy of the ER, known as ER-phagy, require molecular delineation, particularly in vivo. It is unclear how these events control ER proteostasis and cellular health. Here, we identify cell-cycle progression gene 1 (CCPG1), an ER-resident protein with no known physiological role, as a non-canonical cargo receptor that directly binds to core autophagy proteins via an LI...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2018
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.217364